Active Ingredients - Nano-Nutrient Complex: Horsetail Plant Silica Extract, Devils Claw Root, Stinging Nettle Leaf, Boswellia, Mucopolysaccharide Concentrate, Genistein, Glycine, Alanine, Serine, Proline, Collagen, Hyaluronic Acid, Epigallocatechin 3-gallate (EGCG), Cyplexinol® Yucca Root, White Willow Bark, Bone Morphogenetic Proteins (BMPs), Cinnamon Bark, Celery Seed, Meadowsweet, MSM, Corn Silk, Angstrom Minerals, Black Radish Root. Spirulina, Nexrutine.
Other Ingredients: Purified Spring Water, Kosher Vegetable Glycerin, Natural Flavors, 10% Organic Cane Alcohol.
Indications for Use: Pain, Inflammation, stiffness, swelling, wounds, sport injuries, traumatic injuries, post-surgery healing, connective tissue issues, support & nourish the joints, bone and cartilage growth
Benefits of NuJoint Key Ingredients
Stimulate Bone and Cartilage Growth - See More Detailed Ingredient Explanations Below
- Cyplexinol® - a patented protein complex
- Bone Morphogenetic Proteins (BMPs). BMPs are clinically proven to stimulate cells that grow bone and cartilage.
- EGCG - protects cartilage degeneration and reduces inflammation
Reduce Pain & Inflammation
- Nexrutine® - NuJoint contains Nexrutine®, a patented compound extracted from Phellodendron amurense trees (cork tree bark). Nexrutine is proven to reduce pain and inflammation as a COX-2 inhibitor.
Support & Nourish the Joints
Bone Morphogenetic Proteins (BMPs)
- Mucopolysaccharide (MPs) - MPs react with the "bricks" of connective tissue, collagen and elastin, to maintain the normal function and structural integrity of the joints.
- Hyaluronic acid - HA is useful for lowering pains and tenderness associated with degenerative joint diseases.
- Glycine - Glycine plays a part in the formation of collagen, promoting the growth and function of joints, tendons and ligaments.
- MSM - An organic sulfur-containing compound that’s used to improve immune function, lower inflammation and help restore healthy bodily tissue.
- Alanine - plays a key role in maintaining glucose levels and thus energy supplies in the body.
- Herbal Joint Support Blend - Provides a synergistic blend of phytonutrients designed to help support joint function, joint mobility and a healthy inflammatory response.
NuJoint contains Cyplexinol®, Cyplexinol™ is a patented protein complex derived through a proprietary cold extraction process. Biochemically, Cyplexinol® is comprised of a specialized collagen complex with bio-active proteins and growth factors, known as Bone Morphogenetic Proteins (BMPs): (Transforming Growth Factor Beta (TGF-ß), Insulin-like Growth Factor (IGF), Platelet Derived Growth Factor (PDGF), and Basic Fibroblast Growth Factor (bFGF). It is this entire complex which acts uniquely in the body, binding to receptors for rapid onset of action. BMPs are clinically proven to stimulate cells that grow bone and cartilage, a natural process known as osteoinduction.
Osteoinduction is a natural bone and cartilage forming process that occurs by stimulating and transforming key cells in the body (known as mesenchymal stem cells) into osteoblasts (bone forming cells) and chondrocytes (cartilage forming cells). During the formative years, the body’s natural ability to create bone and cartilage is at its greatest. In patients with chronic bone and/or joint conditions this natural homeostasis is lost. Cyplexinol® activates the tissue-growing process again, bringing the body back into natural homeostasis.
This complex was first discovered in the early 1960’s by Dr. Marshall Urist, an orthopedic surgeon at UCLA, who discovered that these proteins stimulate cells responsible for growing bone (osteoblasts) and cartilage (chondrocytes). Since this discovery, there have been over 15,000 studies published supporting both the entire complex and the individual bio-active proteins (BMPs) in their role of growing bone and cartilage tissue, both as a surgical complex and oral nutritional ingredient.
NuJoint contains Nexrutine®, a patented compound extracted from Phellodendron amurense trees (cork tree bark). Nexrutine is proven to reduce pain and inflammation as a COX-2 inhibitor.
Cyplexinol™ is a patented protein complex derived through a proprietary cold extraction process. Biochemically, Cyplexinol® is comprised of a specialized collagen complex with bio-active proteins and growth factors, known as Bone Morphogenetic Proteins(BMPs):(Transforming Growth Factor Beta (TGF-ß), Insulin-like Growth Factor (IGF), Platelet Derived Growth Factor (PDGF), and Basic Fibroblast Growth Factor (bFGF). It is this entire complex which acts uniquely in the body, binding to receptors for rapid onset of action. BMPs are clinically proven to stimulate cells that grow bone and cartilage, a natural process known as osteoinduction.Osteoinduction is a natural bone and cartilage forming process that occurs by stimulating and transforming key cells in the body (known as mesenchymal stem cells) into osteoblasts (bone forming cells) and chondrocytes (cartilage forming cells). During the formative years, the body’s natural ability to create bone and cartilage is at its greatest. In patients with chronic bone and/or joint conditions this natural homeostasis is lost. Cyplexinol® activates the tissue-growing process again, bringing the body back into natural homeostasis. This complex was first discovered in the early 1960’s by Dr. Marshall Urist, an orthopedic surgeon at UCLA, who discovered that these proteins stimulate cells responsible for growing bone (osteoblasts) and cartilage (chondrocytes). Since this discovery there have been over 15,000 studies published supporting both the entire complex and the individual bio-active proteins (BMPs) in their role of growing bone and cartilage tissue, both as a surgical complex and oral nutritional ingredient.
Beta-alanine is a naturally occurring non-essential amino acid. Alanine is the building block of carnosine, a molecule that helps buffer acid in muscles, increasing physical performance and carnosine can also offer itself to build new tissue.
The amino acid alanine is a cofactor with carnosine for bone creation, plus it supports the production of collagen. Collagen is a protein which is the basic component of various connective tissues (such as cartilage) and bone. In this way, alanine supports growth of the osteoblasts where bone mass is formed.
Serine, also known as L-Serine, is a non-essential amino acid. L-Serine is used to make every cell in the human body so it plays a really critical role in health. Though serine provides a number of health benefits, its primary use in our body is to facilitate the performance of the central nervous system, in addition, to the general functioning of the brain.
Serine also facilitates the creation of immunoglobulin and antibodies, which are both indispensable for a robust immune system. This amino acid is needed to produce tryptophan, which is utilized to produce serotonin. Serotonin is employed by the brain to control mood, nervousness, and depression. These are all related to the absence of either tryptophan or serotonin in our body.
Glycine can be synthesized from Serine and used to build articular chondrocytes cartilage.
Proline, also known as L-proline, is an amino acid. It is especially important in the production of collagen, which is a primary component in skin, cartilage, and bone.
Proline production increases during times of soft-tissue trauma, injury, and wound healing, such as muscle or tendon recovery, severe burns, and after surgery. Proline is an important compound in medical dressings that use collagen fragments to stimulate wound healing. A lack of proline in the body might be responsible for strains or tears in soft tissue and slower-than-normal healing. Therefore, after a soft tissue injury, proline or products containing proline, promotes adequate collagen production and sufficient wound healing.
Collagen is the body’s most abundant protein. It acts as a building block of bones, tendons, ligaments, skin, hair, and nails. Collagen comes from the Greek word glue because that is essentially what it does. Collagen forms our connective tissue and works like a glue that holds everything together.
Arthritis causes the collagen in joints to break down faster than it can be replenished, which results in joint pain and decreased mobility. “Scientists have been experimenting with administering collagen for treating arthritis since the 1980s,” said Brooke Russell, a microbiologist and professor at the Texas A&M Institute of Biosciences and Technology in Houston. Collagen is one of the body’s building blocks. So, it’s not surprising that it has so many health benefits, ranging from your skin and gut to your bones and joints.
Soy isoflavones (Genistein and Daidzein) are compounds found in a wide variety of foods, but, mostly soy, that affects a wide-variety of body systems.
They are generally good at cardio protection from reducing lipoprotein levels and are seen as good for bone health in the aging, as well.
The anti-osteoporotic effects (prevent fragility fractures and improve bone quality) of Genistein are highly mediated via the ERa receptor (proliferative subset) and are drastically augmented with forms of mechanical resistance (exercise).
Spirulina is a microalgae that has been consumed for centuries due to its high nutritional value and health benefits. Spirulina is a blue-green microalgae that typically grows in freshwater lakes, natural springs, and saltwater in subtropical and tropical climates.
“Spirulina contains beneficial fatty acids such as DHA and GLA, as well as, high antioxidant levels that can help protect the body against oxidative damage,” says Nathalie Rhone, RD, a nutritionist at Nutrition by Nathalie in New York City.
The blue-green algae is also packed with nutrients, including calcium, niacin, potassium, magnesium, B vitamins, and iron. “Calcium, potassium, and magnesium are all crucial for muscle, bone, and heart health, while B vitamins are responsible for our energy,” says Brown. Magnesium also helps lower stress levels.
Devils Claw Root
Devil's claw was introduced to Europe in the early 1900s, where the dried roots have been used to restore appetite, relieve heartburn, and reduce pain and inflammation. Today, devil's claw is used widely in Germany and France to fight inflammation or relieve arthritis pain, headache, and low back pain.
Several studies show that taking devil's claw for 8 to 12 weeks can reduce pain and improve physical functioning in people with osteoarthritis. One 4-month study of 122 people with knee and hip osteoarthritis compared devil's claw and a leading European medication for pain relief. The people who took devil's claw had as much pain relief as the people who took the medication. Those who took devil's claw had fewer side effects and needed fewer pain relievers throughout the study.
An analysis of 14 studies using devil's claw to treat arthritis found that higher quality studies showed devil's claw may relieve joint pain. And, a review of 12 studies using devil's claw for treating arthritis or low back pain found that devil's claw was at least moderately effective for arthritis of the spine, hip, and knee.
Stinging Nettle Leaf
Stinging nettle, or urtica dioica, is a perennial flowering plant that has been used medicinally for ages, dating back as far as Ancient Greece. Today, it can be found all over the world, but its origins are in the colder regions of Europe and Asia. It grows best in nitrogen-rich soil.
When processed and used medicinally, stinging nettle has a number of helpful health benefits, according to the Department of Dermatology at the Penn State University College of Medicine.
Most stinging nettle products are made from the stem and leaves, but the roots also have pharmacological qualities. The herb has anti-inflammatory qualities that can affect treatment of many health issues. The aboveground parts have typically aided in allergy relief and other breathing-related problems. The roots are able to provide relief for urinary disorders and enlarged prostate as well.
Despite its reputation for pain, stinging nettle is used to help a number of ailments. Studies have shown it has antioxidant, antimicrobial, anti-ulcer, astringent and analgesic capabilities.
According to the University of Maryland Medical Center, the plant has been used most commonly throughout history as a diuretic and for treating painful muscles and joints, eczema, arthritis, gout, and anemia. It is also used to treat urinary issues, as well as, allergies and joint pain.
Arthritis sufferers often experience joint pain, typically in the hands, knees, hips, and spine. Nettle works alongside nonsteroidal anti-inflammatory drugs (NSAIDs) to allow patients to decrease their NSAID use. Because prolonged use of NSAIDs can cause a number of serious side effects, this is an ideal pairing.
Studies also show that applying nettle leaf topically at the site of pain decreases joint pain and can treat arthritis. When taken orally, nettle helps provide pain relief. Another study published in the Journal of Rheumatology shows stinging nettle’s anti-inflammatory power against other autoimmune diseases like rheumatoid arthritis.
Boswellia, or Indian frankincense, is a resin herbal extract from the boswellia tree. Its natural medicine properties have been used for centuries. Its anti-inflammatory effects mean that it may help with inflammatory conditions, such as rheumatoid arthritis, inflammatory bowel disease, and asthma.
Yucca, also known as cassava, yuca, Brazilian arrowroot or Manihot esculenta, is a type of shrub native to South America. It is often cultivated in tropical regions for its starchy root, which is considered a dietary staple for an estimated half billion people around the world. In fact, after corn and maize, yucca root is considered the third largest source of carbohydrates in the tropics.
Keep in mind that yucca root is unrelated to the yucca plant, which is a genus of perennial shrubs and trees that produces white yucca flower clusters, as well as, yucca fruit. Many of these plants are used medicinally and also consumed in many different dishes.
Arthritis is a condition characterized by painful swelling and stiffness in the joints. Thanks to its rich content of both antioxidants and manganese, incorporating yucca root into your diet may be especially useful in providing relief from rheumatoid arthritis and other inflammatory symptoms.
Manganese is often recommended as a natural remedy for arthritis and one study published in the American Journal of Epidemiology even showed that manganese supplementation are associated with a lower risk of rheumatoid arthritis in older women. Similarly, the antioxidants in yucca root may also be especially beneficial in alleviating inflammation and reducing arthritis symptoms, with one study from India reporting that people with rheumatoid arthritis had significantly lower serum concentrations of antioxidants than those without arthritis.
White Willow Bark
Because frequent use of anti-inflammatory drugs and nonsteroidal anti-inflammatory drugs (NSAIDs) and other pain medications are now linked with a growing number of health concerns, many people are interested in using natural painkillers as alternatives. One option, called white willow bark — which has been utilized in folklore and natural medicines for centuries — shows promise for treating pain naturally with little risk of side effects.
White willow trees (salix alba) grow a bark that contains the chemical called salicin, which has anti-inflammatory effects.
Salicin works in similar ways as acetylsalicylic acid, the active ingredient in aspirin. In fact, in the 1800s, salicin was used to develop aspirin.
Willow trees are members of the Salicaceae plant family and are native to Europe, Central Asia, and Northern Africa.
Some research has demonstrated that white willow bark can help people dealing with chronic joint pain and injuries.
Cinnamon is a powerful spice that has been used medicinally around the world for thousands of years. It is still used daily in many cultures because of the widespread cinnamon benefits, not to mention its distinctly sweet, warming taste and ease of use in recipes.
Researchers have concluded that cinnamon health benefits can be obtained in the form of its pure bark, essential oils, in ground spice form (which is bark powder) or in extract form when its special phenolic compounds, flavonoids and antioxidants have been isolated. These compounds make cinnamon one of the most beneficial spices on earth, giving it antioxidant, anti-inflammatory, anti-diabetic, anti-microbial, immunity-boosting, and potential cancer, and heart disease-protecting abilities.
Celery, which has the scientific name Apium graveolens, is a vegetable in the plant family called Apiaceae. It’s an extremely old vegetable, with records showing that parts of the plant were found in the tomb of the pharaoh “King Tutankhamun,” who died in 1323 B.C.
Celery contains antioxidants and polysaccharides that are known to act as anti-inflammatories, especially flavonoid and polyphenol antioxidants. Research indicates these support overall health, especially as someone ages, by fighting free radical damage (or oxidative stress) that can lead to cellular damage and inflammation.
Researchers have identified over a dozen different types of nutritional compounds and antioxidants that are responsible for the benefits of celery products. These include phenolic acids like caffeic acid and ferulic acid, plus flavanols like quercetin.
Due to its inflammation-lowering potential, celery it may be useful for treating a wide range of conditions that are made worse by inflammation, including joint pain (such as from arthritis).
Meadowsweet has a long and distinguished history of medicinal use and is mentioned in some of the most famous literary works of the middle ages.
It is kown to be rich in salicylic acid (of Willow bark fame), which is effective for pain relief and was touted many centuries ago as being an excellent remedy for moderate pain, especially pain in a fixed area of the body, such as headaches.
Containing salicylic acid, Meadowsweet is an effective herb against inflammation. It is now thought that most diseases can be traced back to chronic low-level inflammation, making this herb an extremely useful tool in your natural health kit. Salicylic acid is more famously known to come from Willow; however, the other compounds within Meadowsweet make it much easier on the lining of the stomach.
The anti-inflammatory action of these salicylates makes Meadowsweet effective against rheumatic pain, while its tannin and mucilage content appear to buffer the adverse effects of isolated salicylates which can cause gastric irritation. Aspirin, on the other hand, can cause gastric ulceration.
It has also been mentioned in various herbal compendiums including those written by Culpeper and Gerard. Culpeper believed that Meadowsweet could be used to dry the body out, stop bleeding, vomiting, diarrhea, and excessive menstruation.
The traditional use of Corn Silk can be traced back to the Mayans, Incans, and Native Americans, who used it to treat bladder and urinary disorders and as a poultice for bruising and swelling. The Native Americans also showed the European settlers how to brew a healing tea from Corn Silk.
Corn Silk is known for its anti-inflammatory properties. Traditional medicine followers are of the view that it can be used to reduce the pain caused by inflammatory ailments like gout and arthritis. The diuretic action of Corn Silk may prevent excess uric acid formation in the body joints, which leads to gout pain.
Horsetail Plant Silica
Horsetail (Equisetum arvense) is an herb in the Equisetaceae family of plants, which have been used since ancient Greek and Roman times. It was traditionally used as a medicinal herb to treat osteoporosis, tuberculosis, and kidney problems; it was also used as a diuretic (for relief of fluid retention) and to stop bleeding and heal wounds.
Horsetail contains silicon, a mineral needed for healthy bone and connective tissue production. The chemicals in horsetail are thought to have anti-inflammatory (reducing inflammation) and antioxidant (chemicals that help boost the immune system) properties. Horsetail contains silica, silicon and minerals that work together to strengthen the hair and nails, as well as promoting healthy bone tissue. Selenium is also found in horsetail; this is a mineral, known to support the thyroid, cognitive and even helps some with hair growth.
MSM (methylsulfonylmethane) is an organic, sulfur-containing compound that is used to improve immune function, lower inflammation, and help restore healthy bodily tissue. The reason so many benefits are attributed to the MSM supplement is because MSM provides biologically active sulfur, which is the fourth most plentiful mineral in the body and needed for many different critical bodily functions every single day.
A well-researched benefit of MSM is that it helps decrease joint inflammation, improves flexibility, and restores collagen production. Research shows that many patients with arthritis, joint pain, stiffness, knee/back problems, and a limited range of motion experience, a reduction in symptoms and improved quality of life when taking an MSM supplement.
MSM is beneficial for helping the body form new joint and muscle tissue, while lowering inflammatory responses that contribute to swelling and stiffness. MSM is a natural and effective anti-inflammatory because of how sulfur impacts the immune system and facilitates normal cellular activity. Sulfur needs to be present for our cells to release many byproducts and excess fluids that can accumulate and cause swelling/tenderness.
A clinical trial testing the effects of MSM on joint pain in 118 patients with osteoarthritis found that compared to a placebo, MSM supplements taken over 12 weeks resulted in more improvements in pain, swelling and joint mobility.
Epigallocatechin 3-gallate EGCG
Green tea's active ingredient, epigallocatechin 3-gallate (EGCG), has gained significant attention for its ability to protect cartilage degeneration and reduces inflammation as a pro-inflammatory cytokines inhibitor.
Black Radish Root
The black radish, or the Black Spanish radish, is a member of the Cruciferae family and has been in use for centuries, both as a medicine and as food. It is scientifically known as Raphanus sativus L. Var. niger and may have originated from the eastern Mediterranean region. It is referred to as the black radish due to its dark purple or sometimes dark exterior, though it does come with a white, inner flesh.
Since ancient times, black radish has been used by the Chinese, Indians, and Europeans to treat different illnesses. Other regions have started growing the black radish, and its popularity has increased in recent years as a result of its impressive nutritional profile and fantastic health benefits.
The black radish is slightly larger than the traditional radish and more bitter and pungent in flavor. This is as a result of the chemical compounds such as glucosinate, Isothiocycinate, and myrosinase produced by the plant. Its not-so-appetizing flavor is offset by the tons of health benefits it provides. The black radish has earned the moniker ‘the black magic’ due to its antibacterial and antimicrobial content, as well as, being a powerhouse of nutrients, antioxidants, and anti-inflammation.
Angstrom Mineral Blend
Angstrom minerals are composed of the smallest possible particles in a mineral supplement. In fact, the term “angstrom” is actually a unit of measurement equaling one ten billionth of a meter. While we can’t see a particle this tiny with our own eyes, scientists can prove that the minerals in these liquid supplements are that small. When an individual consumes angstrom minerals, cells in the body are able to absorb them almost immediately thanks to their minuscule size.
Angstrom minerals have become increasingly popular in recent years. The reason for this increase in popularity can be attributed to more developed studies regarding the health benefits of these minerals. Natural health experts and scientists have both found a long list of positive effects associated with angstrom minerals. Among the many benefits of regularly consuming angstrom minerals are improvements in the function of the digestive, immune, and endocrine systems and better focus and concentration.
Possibly the most important benefit of angstrom minerals is their ability to decalcify the body. Calcification occurs when certain minerals, which are too large to be easily absorbed by cells, enter the body. As a result, these minerals accumulate and cause calcification in the body. Angstrom minerals can help to remove this calcification, which can, in turn, help to prevent disease.
According to Dr. Bruce W Halstead, medical director of the Halstead Preventive Medical Clinic, Mucopolysaccharide (MPs) are as important in nutrition as amino acids, essential fatty acids, vitamins, and minerals. The MPs react with the "bricks" of connective tissue, collagen, and elastin, to maintain the normal function and structural integrity of the joints, arteries, heart, brain, skin, and other tissues. They form cross-linkages with proteins such as collagen, the basis of cartilage. In short, they act as the internal structure of tissue, holding all cells together; thus, maintaining the elastic gel nature of connective tissue. Mucopolysaccharide Concentrate has been scientifically formulated to contain naturally occurring glycosaminoglycans which have been extracted using papain hydrolysis to facilitate maximum tolerance by the body in addition to complete absorption for optimal results.
Warning: If pregnant, breastfeeding, taking any medications, or have a medical condition please consult your doctor before use. Keep away from children. Use only if safety seal is intact.
Health Disclaimer:These statements have not been evaluated by the Food & Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease. The information contained herein is for informational purposes. Please be sure to consult your physician before taking this or any other product. Consult your physician for any health problems or before starting a new program.