Active Ingredients: Nano-Nutrient structured Complex: Evening Primrose Flower, Blue Lotus (Nymphaea caerulea), White Lotus (Nelumbo nucifera), Coca Leaf (Erythroxylum var. Novogranatense) decocanized, Kanna (Sceletium Tortuosum), Jujube Fruit (Ziziphus Jujuba), Motherwort (Leonurus cardiac), Blue Vervain (Verbena hastate), Skullcap (Sctellaria Laterifolia). Non GMO Neurotransmitters Support: GABA (Gamma Amino Butyric Acid), Noopept, L-Glutamine, L-Tyrosine, L-Tryptophan.
Other Ingredients: Purified Spring Water, Kosher Vegetable Glycerin, Organic Alcohol.
Servings per Container: 30 day-supply when used as directed/recommended.
Indications for Use: Quick stress relief; deep state of relaxation; reboot from stress; worries; supports meditation & tranquility; counteract the fight or flight response; turn on rest & digest; non-habit forming; turn off mind chatter; unwind and fall asleep.
Warning: If pregnant, breastfeeding, taking any medications, or have a medical condition please consult your doctor before use. Keep away from children. Use only if safety seal is intact.
Benefits of InstaCalm Key Ingredients
Blue Lotus / White Lotus
The powerful lotus plant has been used in East and Southeast Asian traditional medicine and cuisine for centuries. There are over 100 species of lotus. This plant’s medicinal usage goes back generations but the science behind its potential has only recently come under study. Today most people prefer a more natural solution for their health as compared to other traditional medicines. And, for this reason, herbs such as white and blue lotus flower extract are gaining much popularity.
Here are four hidden benefits of this popular herbal supplement (white & blue Egyptian lotus) you should know about. When these two are used together they have a synergistic effect.
1-Improved Spiritual Awareness
Those who take blue & white lotus supplements (available in the form of seeds, essential oil, tea, powders, and extract pills) regularly report that they feel a heightened sense of awareness. This unique supplement makes people more aware of their emotions and more connected to their spiritual side.
Blue & white lotus plant extract also helps to manage common ailments like stress and anxiety. And those struggling with depression also report that they feel an improved sense of well-being when they take the lotus herbal supplements regularly.
2-Chronic Pain Relief
The Ancient Egyptians discovered its pain relieving properties and, for this reason, lotus has been used ever since to help manage the symptoms of various ailments.
In modern times, it has been used to alleviate the pain associated with serious illnesses such as arthritis and cancer. In addition to tea and powders, blue and white lotus are also found in tincture form.
3-Sharper Mind and Memory
Have you noticed lately that you’re not remembering things as well as you used to? Blue lotus flower can help with this. Users report improved memory, as well as, a heightened sense of spiritual awareness. The Blue lotus herb helps promote a healthier circulatory system which means that blood flows through the body more easily. The sharper mind and memory are a result of the increased circulation to the brain. Blue lotus, thus, helps expedite the process of forming memories.
4-Heightened Sexual Side Effects
Perhaps the most common of blue lotus effects is heightened sexual experiences. In fact, the herb has even been called a natural Viagra and the best part is that it works equally for both men and women. Health experts suspect that the increased sexual pleasure is a result of the improved circulation we mentioned previously, as well as, the deeper emotional awareness.
Nymphaea Caerulea (blue lotus) has been found to provide relief from different kinds of stress and anxiety. The roots of this plant have been shown to help promote relaxation and give a sense of euphoria. Users have reported that a cup of blue lotus tea makes them less anxious and gives them restful sleep.
Coca Leaf (decocainized)
South American Indians have used coca leaf as a remedy for thousands of years. Coca might be useful as a treatment for gastrointestinal ailments and motion sickness, as a fast-acting antidepressant medication, a substitute stimulant for coffee in certain cases, and as an adjunct in programs of weight reduction and physical fitness. In leaf form, coca does not produce toxicity or dependence. The alkaloids in the coca plant, which affect the neurons in the brain, act as a natural antidepressant as they improve the mood. Coca blocks the normal signal transmission of dopamine, serotonin, and norepinephrine, causing them to build up in the brain, leading to improved mood.
Kanna elevates mood and decreases anxiety, stress, and tension, and it has also been used as an appetite suppressant by shepherds walking long distances in arid areas. Both the traditional tribespeople and modern-day Rastafarians of Southern Africa know a thing or two when it comes to boosting their moods on a bad day. This centuries-old secret comes in the form of a beautiful succulent called kanna—aka Sceletium tortuosum—a plant native to the S. African region, still largely unknown in North America.
Modern research now supports the efficacy of this traditionally employed compound for enhancing positive mood and cognitive function, reducing stress, and inducing calm without sedative effects and, very importantly, without inducing dependency. Two main mechanisms underlie sceletium’s effects. First, it acts as a natural selective serotonin reuptake inhibitor (SSRI). Sceletium binds to serotonin transporters, inhibiting reuptake of this neurotransmitter from the synapse of serotonergic neurons, resulting in an increased serotonin concentration in the synaptic cleft, in the same fashion as prescription SSRIs.
Sceletium’s second mechanism of action is in inhibiting phosphodiesterase-4 (PDE4). PDE4 is an enzyme that hydrolyzes cyclic AMP (cAMP) and is highly expressed in brain regions involved in memory, anxiety, and depression, including the amygdala, nucleus accumbens and hippocampus. Animal models suggest PDE4 inhibitors can reverse depression, improve cognition, and alleviate anxiety. A small, double-blind, placebo-controlled crossover study showed that oral supplementation with sceletium resulted in significant decrease in severity of the threat circuitry of the human brain, which may have positive implications for reducing anxiety. PDE4 inhibitors may have positive effects on cognitive function and overall neurological health by enhancing the differentiation of oligodendrocyte progenitor cells and facilitating acceleration of re-myelination of damaged cells in the central nervous system. Moreover, it has been suggested that SSRIs and PDE4 inhibitors work synergistically, because use of SSRIs may upregulate PDE4 activity, subsequently reducing sensitivity to SSRIs over the long-term. Therefore, a compound capable of both actions may be more effective and have broader therapeutic utility than either intervention on its own. The two major alkaloids in sceletium—mesembrine and mesembrenone—are responsible for most of the extract’s effects. Mesembrine is the predominant serotonin reuptake inhibitor (SRI), while mesembrenone is a dual SRI and PDE4 inhibitor.
Evening Primrose Flower
Evening primrose has served as both food and medicine throughout history. The Native Americans boiled and ate the root while using a poultice made from the leaves, for bruises, and as an herbal remedy for hemorrhoids. The European settlers took it back to the continent as a food. Today, evening primrose is still used for food, with the leaves and flowers being added to salads and the root being eaten as a vegetable.
The oil from the leaves and seeds is used in creams and salves to relieve the itching and redness of skin conditions, such as eczema. It is also used to help with a wound and burn to heal.
The oil, extracted from the seeds, contains the essential fatty acids (EFA) gamma-linolenic acid (GLA) and linoleic acid, which are Omega-6 fatty acids. These EFAs have been found to improve cardiovascular health, improve utilization of insulin and regulating moods. The dried flower buds of Evening Primrose are used medicinally. It is useful for Blood-fat-reducing, anti-atherosclerosis, losing weight, anti-arrhythmia, and anti-inflammatory.
The whole plant is a sedative and, in modern days, a tincture has been used with success in extreme sensitiveness, restlessness, and insomnia. The whole plant has somewhat expectorant qualities. An infusion of the flowers was formerly considered excellent against nervous hysterical disorders. In modern herbal medicine the infusion of the root is generally taken as a good remedy against nervous headaches.
A member of the Lamiaceae family, this plant has a long history of use in western botanical medicine. It is used to support exhausted nerves resulting from mental and physical exhaustion, maintain normal balance in times of muscular tension, and to support normal sleep patterns. It is trophorestorative to the nervous system meaning it restores nutrition uptake to the nerves. Like most herbs in the mint family, it is cooling yet has other complex chemicals making it a balanced choice as a gentle nervine.
Skullcap has a calming and relaxing effect on the body and can be used during the day to restore balance to an overworked individual or, in the evening, to promote normal healthy sleep.
This small, shrub-like plant is native to areas of Asia and Australia, as well as Southern Europe and parts of the southern United States. Zizyphus jujuba— commonly known as jujube—has an edible fruit that is similar to a date. Sweet and fiber-rich, the jujube fruit is packed with nutritional value, a good source of vitamins A, B & C, minerals including iron, phosphorus, and calcium, and healthful fatty acids.
Jujube has been employed for thousands of years in traditional Chinese medicine, including as a sedative, an anxiety reliever, and a digestive aid.
As a sedative, two types of phytochemicals in jujube, saponins and flavonoids, trigger changes to neurotransmitters, including GABA and serotonin, which can make it easier to fall asleep and stay asleep. At least one of the saponins in jujube, jujuboside A, helps to quiet activity in the hippocampus region of the brain. And jujube contains a flavonoid compound, spinosin, which appears to trigger sleepiness through its effects on serotonin. These are some of the explanations scientists have identified to-date for jujube’s sedative effects.
The same saponin and flavonoid compounds that work to relax and promote sleep also appear to provide jujube’s anti-anxiety effects.
Motherwort (Mother’s Herb, Wort=Herb). This perennial plant in the mint family is not only a beautiful flowering plant, but a beautiful addition for anyone wishing to gently tonify the female reproductive system and support healthy levels of stress, particularly those affecting women. In a personal communication from renowned Herbalist Rosemary Gladstar, she related that she has seen very positive results in use of this herb with Mom’s combating "empty nest" syndrome and the feelings that transition can bring. Many herbalists consider this plant one of the best for “gladdening and strengthening the heart”. The herb has been used traditionally by many cultures, European, Native American, Chinese, and North American Herbalists for a variety of endocrine related issues, and as a tonic for women’s uterine health.
Motherwort is a nervine particularly effective in supporting healthy reproductive function in women, especially those influenced by tension and stress. The plant also supports healthy cardiovascular function and, as indicated in its botanical name, early Greek Physicians used the herb for this purpose.
Vervain is also referred to as American blue verbena, simpler's joy, holy herb, mosquito plant, and wild hyssop. In traditional Chinese medicine, it is known as ma bian cao.
Verbena tea has long been believed to have a calming effect that can help relieve stress and promote sleep. This effect was first described in the 1652 book The English Physician in which vervain was used as a tea to treat "over-enthusiasm."
There is evidence that Vervain officinalis not only reduces anxiety and insomnia but may prevent the occurrence of epileptic seizures. These effects are attributed to a sugar molecule in vervain, known as verbenalin, which is believed to have psychoactive properties.
A 2016 study published in the Frontiers of Pharmacology reported that an extract of Vervain officinalis, prescribed at a dose of 100 to 500 milligrams per kilogram, reduced the frequency and duration of tonic-clonic seizures in mice.
Moreover, mice injected with the extract spent more time sleeping than those injected with a placebo. Anxiety, measured by movement through a maze, was also seen to improve. While it is unclear if the same effect would be rendered in humans, it does suggest that Vervain officinalis may exert a positive influence on the central nervous system and adrenal glands (which produce stress hormones).
Gamma-Aminobutyric acid is an amino acid produced naturally in the brain. GABA functions as a neurotransmitter, facilitating communication among brain cells. GABA’s big role in the body is to reduce the activity of neurons in the brain and central nervous system which, in turn, has a broad range of effects on the body and mind, including increased relaxation, reduced stress, a more calm, balanced mood, alleviation of pain, and a boost to sleep.
Many medications interact with GABA and GABA receptors in the brain, altering their function to achieve certain effects, typically relaxation, pain relief, stress and anxiety reduction, lower blood pressure, and improved sleep. Barbiturates, anesthetics, benzodiazepines, antidepressants, and anti-seizure medications are some of the medications that target GABA.
A number of natural supplements also affect GABA activity, to help relieve stress and anxiety, promote a balanced mood, and help with sleep. Valerian and hops, magnesium, and L-theanine, all of which have an effect on the brain’s GABA activity. Other natural supplements that may affect GABA activity include L-arginine, kava, passionflower, and American ginseng.
You could call GABA the brakes of the brain. It is the body’s most important inhibitory neurotransmitter, which means it lowers the activity of neural cells in the brain and the central nervous system, having the effect of moving the brain and the body into a lower gear. By inhibiting neural activity, GABA facilitates sleep, reduces mental and physical stress, lowers anxiety, and creates a calmness of mood. GABA also plays an important role in regulating muscle tone. GABA is an important contributor to the body’s overall mental and physical homeostasis, or balance.
Noopept is the brand name for N-phenylacetyl-L-prolylglycine ethyl ester, a nootropic (may improve cognitive function, particularly executive functions, memory, creativity, or motivation, in healthy individuals) molecule.
It provides a mild cognitive boost after supplementation and also provides a subtle psychostimulatory (boost to Nervous System) effect. It also provides a general neuroprotective effect after supplementation. This neuroprotective effect occurs during various states of cognitive trauma, including oxidative stress and physical trauma.
Glutamine is an important amino acid with many functions in the body. An abundant supply of glutamine makes it easier for the brain to maintain neurotransmitter balance, by increasing the production of glutamate when required for alertness, learning and memory, and the production of GABA when its inhibitory properties are needed. It fuels two of the brain’s most important neurotransmitters: glutamic acid and gamma-aminobutyric acid (GABA).
L-Tyrosine is an amino acid that is used to produce noradrenaline and dopamine; it appears to reduce stress during exposure to acute stressors (which tend to deplete noradrenaline) and may help to prevent stress-induced memory deficits.
L-Tryptophan is an essential amino acid that is a precursor to the neurotransmitters serotonin and melatonin. Supplementation with tryptophan has been shown in numerous clinical trials to be safe, well tolerated, and supportive of well-being, calmness, relaxation, sleep.