A More Effective and Cheaper Way

to Get Stem Cells

KO Gardens Nutrition August 2023 Article

You may have heard about all the exciting health discoveries researchers are making with stem cells. Such cells can renew and develop into any new cell your body needs. So if your knees need new cartilage, stem cells can help rebuild it.

The problem with stem-cell therapy is that it’s expensive and it doesn’t always work. Some people spend a lot of money and are disappointed with the results.

Researchers have found that it’s far better to stimulate your body to make its own stem cells than inject such cells into the problem area. What’s remarkable is that there’s a simple and affordable way to do so by using regulatory peptides.

Regulatory peptides are small proteins that play a crucial role in various bodily processes, including cell growth, differentiation, and regeneration. In recent years, researchers have found that these regulatory peptides can reactivate adult stem cells. One of the primary ways that happens is through the activation of specific signaling pathways. These signaling pathways are responsible for controlling various cellular processes, such as the creation of new cells, cell movement, and the characteristics that each cell develops. By activating these pathways, regulatory peptides can stimulate the growth and differentiation of adult stem cells, which aids tissue repair and regeneration.

Research has shown that certain regulatory peptides, such as some known as growth factors and cytokines, can cause cells to multiply and take on other characteristics. For example, epidermal growth factor (EGF) has been shown to grow neural (nerve) stem cells, while bone morphogenetic protein (BMP) can cause mesenchymal stem cells (versatile cells that can develop different characteristics) to grow into osteoblasts, which are bone-forming cells.

Regulatory peptides can also work with other factors to rejuvenate stem cells. For instance, studies have shown that the combination of regulatory peptides and extracellular matrix (ECM) components can help adult stem cells thrive and develop specialized characteristics. Additionally, they can provide physical support for the cells and promote tissue regeneration.

Bringing adult stem cells back to health and vitality through the use of regulatory peptides is promising for the treatment of many diseases and injuries. By stimulating the growth and differentiation of stem cells, these peptides can improve tissue repair and regeneration. It’s a non-invasive and cost-effective approach to stem cell therapy, making it available to far more people than ever before.

Clearly, regulatory peptides play a critical role in the renewal of adult stem cells, and more and healthier stem cells aid tissue repair and regeneration. The potential for such adaptable, organic, and internally directed treatment of various diseases and injuries is huge and potentially game changing.

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Sources:

1. Liu, H., Zhu, S., Zhang, C., Lu, P., Zhu, T., Gong, X., & Cui, Y. (2018). The reactivation of adult stem cells in response to tissue injury. Cell Regeneration, 7(1), 1-13.

2. Ranganath, S. H., Levy, O., & Inamdar, M. S. (2012). Harnessing the mesenchymal stem cell secretome for the treatment of cardiovascular disease. Cell Stem Cell, 10(3), 244-258.

3. Blázquez-Martínez, A., Chiesa, M., Arnalich, F., & Fernández-Delgado, J. (2014). Epidermal growth factor induces the proliferation of rat adult neural stem cells in vitro through Hes1 activation. Stem Cells International, 2014, 1-9.

4. Balmayor, E. R., & Azevedo, H. S. (2015). Reisolation of adipose derived stem cells and their differentiation into osteogenic and chondrogenic lineages. Methods in Molecular Biology, 1235, 269-277.

5. Bae, W. G., Kim, Y. J., Park, J. C., & Kwon, I. K. (2018). Synergistic effect of extracellular matrix components and regulatory peptides on the growth and differentiation of human adipose-derived stem cells. Journal of Biomaterials Science, Polymer Edition, 29(16), 1959-1972.

6. Ren, H., Cao, Y., Zhao, Q., Li, J., Zhou, C., Liao, L., ... & Zhao, Y. (2016). Matrix stiffness-regulated inversion of mesenchymal stem cells: a novel hypothesis for lineage commitment and tissue regeneration. Theranostics, 6(11), 1962-1975.

7. Zhu, Y., Wang, A., Patel, S., Kurpinski, K., Diao, E., Bao, X., ... & Li, S. (2019). Engineering biophysical microenvironments for reactivating quiescent stem cells for muscle regeneration. Stem Cells Translational Medicine, 8(3), 228-239.

8. Shao, Y., Gao, Z., Marks, J. R., & Jiang, X. (2019). Microfluidic adhesion induced by regulatory peptide (MINT) for the capture and release of viable circulating tumor cells. Lab on a Chip, 19(9), 1610-1621.

9. Sarkar, D., Spencer, J. A., Phillips, J. A., Zhao, W., Schafer, S., Spelke, D. P., ... & Spector, M. (2021). Engineered cell and tissue microenvironments for stem cell and regenerative medicine research. Stem Cells and Development, 30(7), 339-357.